Scientific References

(1) Very low calorie diet and 6 months of weight stability in Type 2 diabetes: Pathophysiologic changes in responders and non-responders. Newcastle University. Diabetes Care, March 2016. https://www.sciencedaily.com/releases/2016/03/160322080542.htm

(2) Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism. University of Utah Health Sciences. Cell Metabolism, 2016. https://doi.org/10.1016/j.cmet.2016.10.002

(3) Ceramides - Lipotoxic Inducers of Metabolic Disorders. Baker IDI Heart and Diabetes Institute, Melbourne, Australia. Trends in Endocrinology and Metabolism, October 2015. https://www.ncbi.nlm.nih.gov/pubmed/26412155

(4) Hyperosmolar Hyperglycemic State: A Historic Review of the Clinical Presentation, Diagnosis, and Treatment. Emory University School of Medicine, Atlanta. Diabetes Care, November 2014. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207202/

(5) Amputation Risk in Patients with Diabetes Mellitus and Peripheral Artery Disease Using Statewide Data. Misty D. Humphries, Ann Brunson, Nasim Hedayati, Patrick Romano, and Joy Melnkow. Annals of Vascular Surgery, 2016. ncbi.nlm.nih.gov/pmc/articles/PMC4691363/

(6) Prevalence of Diabetic Retinopathy in the United States, 2005–2008. Centers for Disease Control and Prevention, Atlanta. JAMA, 2010 August. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945293/

(7)The double trouble of metabolic diseases: the diabetes–cancer link. Slavica Tudzarovaa and Mahasin A. Osman, Doug Kellogg, Monitoring Editor, University of California, Santa Cruz. Molecular Biology of the Cell, 2015 September. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569306/

(8) Sex differences in the association between diabetes and cancer: a systematic review and meta-analysis of 121 cohorts including 20 million individuals and one million events. Toshiaki Ohkuma, Sanne A. E. Peters, Mark Woodward. Diabetologia, October 2018. https://diabetologia-journal.org/2018/07/20/diabetes-increases-the-risk-of-cancer-with-a-higher-risk-in-women/

(9)Emerging links between type 2 diabetes and Alzheimer’s disease. Gumpeny R Sridhar, Gumpeny Lakshmi, and Gumpeny Nagamani. World Journal of Diabetes, June 2015.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458503/#B4

(10) National Diabetes Statistics Report. Center for Disease Control and Prevention. February 2018.https://www.cdc.gov/diabetes/data/statistics/statistics-report.html

(11) Cardiovascular Disease and Diabetes. American Heart Association, 2015. https://www.heart.org/en/health-topics/diabetes/why-diabetes-matters/cardiovascular-disease--diabetes

National Diabetes Statistics Report, 2017. Coexisting Conditions and Complications. Center for Diseases Control and Prevention. https://www.cdc.gov/diabetes/data/statistics-report/coexisting.html

(13) Obesity Update 2017. OCDE 2017.https://www.oecd.org/els/health-systems/Obesity-Update-2017.pdf

(14) More Than Half of Kale Samples Tainted by Possibly Cancer-Causing Pesticide. Alexis Temkin, PhD, Toxicologist. March 20, 2019. EWG.org. https://www.ewg.org/foodnews/kale.php

(15) Brown Adipose Tissue Improves Whole Body Glucose Homeostasis and Insulin Sensitivity in Humans. Diabetes, July 2014. https://www.sciencedaily.com/releases/2014/07/140723123944.htm

(16) Glucose uptake in brown fat cells is dependent on mTOR complex 2–promoted GLUT1 translocation. Olsen, J.M et al. Journal of Cell Biology., 2014 http://jcb.rupress.org/content/207/3/365

(17) Rapamycin blocks induction of the thermogenic program in white adipose tissue. Perelman School of Medicine, University of Pennsylvania. Diabetes, 2016.https://diabetes.diabetesjournals.org/content/65/4/927

(18) Glucose uptake in brown fat cells is dependent on mTOR complex 2–promoted GLUT1 translocation. Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University. Journal of Cell Biology. November 2014. http://jcb.rupress.org/content/207/3/365